Upregulation of sICAM-1 and sVCAM-1 Levels in the Cerebrospinal Fluid of Patients with Schizophrenia Spectrum Disorders

Immunological explanatory approaches are becoming increasingly important in schizophrenia research. In this context, the function of blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) (BCSFB) plays an essential role. Different adhesion molecules, such as intercellular molecule-1 (ICAM-1) vascular cell (VCAM-1), key elements sustaining integrity BBB BCSFB. The objectives study were to (1) compare levels different molecules CSF patients with spectrum disorders those unipolar depression (2) analyze their association established markers BBB/BCSFB (CSF total protein albumin quotient (AQ)). Therefore, a 40 disorder 39 age- sex-matched control analyzed. soluble ICAM-1 (s-ICAM-1), VCAM-1 (s-VCAM-1), plasminogen activator inhibitor 1 (PAI-1) measured using magnetic bead multiplexing immunoassay. sICAM-1 (p < 0.001), sVCAM-1 PAI-1 0.001) significantly higher than depression. addition, significant correlation concentrations (r = 0.454, p 0.003) AQ 0.512, was observed. results revealed that These circulating signaling may indicate endothelial dysfunction causing impaired disorders. Consistent view, highly AQs detected. Upregulation these might be indicative proinflammatory immune response underlying disturbance subgroup significance is limited by its retrospective research design absence healthy group. assay used not previously for measurement CSF. Further translational controlled studies role needed.